Brain changes and risk factors causing impaired mobility 

Principal Investigator: Leslie Wolfson, M.D., Professor of Neurology

Co-investigator: Nicola Moscufo

Site: University of Connecticut Health Center

NIH R01 AG022092

Years: 2004-2009


Aim of the study was to advance our understanding of the relationship between vascular disease risk factors (VDRF), occurrence of white matter (WM) lesions in the brain, and mobility. VDRFs include hypertension, orthostatic hypotension, metabolic and hematological conditions such as diabetes, fibrinogen, homocysteinemia, hyperlipidemia, increase of C-reactive protein. The study was conducted on 99 subjects 75 years and older, divided into three groups, mobility-impaired, normal, and transitional mobility. An overview of this longitudinal study is described in Wolfson L. et al. Rapid buildup of brain white matter hyperintensities over 4 years linked to ambulatory blood pressure, mobility, cognition, and depression in old persons. J. Gerontol. A Biol. Sci. Med. Sci. 68(11): 1387-94, 2013

Study-related publications:can be found here

See also: ProjectPast project