Smartphone Application for Quality of Life Assessment

Fatigue Mobile Application

In collaboration with Mobilengine (https://mobilengine.com/), we have developed a mobile application for Android devices which aims to assess fatigue and a multitude of its potential confounders in MS patients in the belief that it will facilitate remote monitoring of symptoms and adverse events, and may allow more timely intervention than is possible with scheduled face-to-face visits. We implemented the following questionnaires: Modified Fatigue Impact Scale; Fatigue Severity Scale; Fatigue, Depression, Anxiety and Sleep Disturbance Questionnaires of Neuro-QOL; 7 questions from the Symptoms of Depression Questionnaire aimed at the vegetative symptoms of depression; Epworth Sleepiness Scale; Godin Leisure-Time Exercise Questionnaire; and Behavioral Avoidance/Inhibition System Scale. We additionally created several questions which aim to identify exacerbators/alleviators of fatigue and a possible diurnal component of fatigue. These questionnaires are assessed only one-time within the first 3 days of use. We also have created a Visual Analogue Scale (VAS) system that tracks patients’ fatigue, anxiety, depression, and pain levels every 4 hours while the patient is awake. We implemented also a Sleep Diary, which assesses sleep habits, including daily sleep time, wake time, and perceived sleep quality. VAS and Sleep Diaries are collected for 2 weeks. In addition, we developed a database that tracks patient responses in real time, and sends daily updates to the investigators via email about the progress of each patient’s tracking.

Publications:

1. Palotai M, Kujbus G, Wallack M, Dalnoki A and Guttmann CR. A mobile application for real-time assessment of fatigue and related symptoms in patients with multiple sclerosis. International Progressive Multiple Sclerosis Alliance (IPMSA) Meeting. 2018: Toronto, Canada.

2. Palotai M, Kujbus G, Wallack M, Dalnoki A and Guttmann CR. A mobile application for real-time assessment of fatigue and related symptoms in patients with multiple sclerosis. 34th Congress of the European Committee for treatment and research in multiple sclerosis. 2018: Berlin, Germany.