Spin-Echo planar spectroscopic imaging for fast lipid characterization in bone marrow

Citation:

S Bao, CR Guttmann, JP Mugler, JR Brookeman, LP Panych, RA Kraft, K Oshio, D Jaramillo, FA Jolesz, DS Williamson, and RV Mulkern. 1999. “Spin-Echo planar spectroscopic imaging for fast lipid characterization in bone marrow.” Magn Reson Imaging, 17, 8, Pp. 1203-10.

Abstract:

Lipid characterization of bone marrow in vivo with proton magnetic resonance spectroscopy was performed using Spin-Echo Planar Spectroscopic Imaging sequences. The methods are shown capable of rapidly generating two-dimensional chemical shift imaging data sets suitable for measuring lipid indices that reflect unsaturation levels among triglycerides, as demonstrated in oil phantoms and bone marrow from a healthy volunteer. The volume coverage, spatial resolution, acquisition speed, and spectral characteristics of Spin-Echo Planar Spectroscopic Imaging should make it attractive for clinical studies of diseases affecting normal lipid chemical composition.